Endocrine Abstracts

Endothelial dysfunction is a key step in the initiation of atherosclerosis, resulting from a decrease in bioavailability of nitric oxide (NO). IGF-1 may play a part in regulation of NO production via the PI3-kinase/Akt/eNOS pathway. We have investigated whether disturbances of this pathway occur in dietary-induced obesity.Obesity was induced in mice fed a high fat diet for 20 weeks (n=12), compared to chow fed controls, with an age-related increas...